The Saratov Airlines jet vanished minutes after taking off from Moscow's Domodedovo Airport and crashed near the village of Argunovo, about 50 miles south-east of Moscow.
All those on board are thought to have died, officials told Russian state media.
The An-148 was en route to the city of Orsk in the Urals, near Russia's border with Kazakhstan. It crashed early in the afternoon today local time.