Wasps will visit Castle Park on Friday, 26 August (7:45pm).
Newcastle Falcons will then face the Knights a week later on Friday, 2 September (7.45pm).
Wasps finished ninth in last season’s Premiership, while Newcastle were 12th.
Knights hope to challenge for promotion after finishing last season in second place, just three points behind Ealing Trailfinders.
The club has submitted a plan to double the capacity of Castle Park - taking it up to 10,015 - in order to meet Premiership requirements.
Knights start their league campaign at Ealing on September 10.