Paul Carter died after a long battle against cancer - an illness he had fought many times, according to the newspaper's online obituary.
Mr Carter began his career in Sheffield in the 1980s as a news reporter and later became a sub-editor at our York Street offices before joining the Daily Express in 1987, where he held a number of senior positions.
He joined the Daily Mail in 2000 and editor Paul Dacre said: "Paul was one of the most brilliant all-round journalists I have worked with and in his 17 years here made an incalculable contribution to the Mail’s success.
"He is a huge loss both to the paper and to the many colleagues whom he befriended and mentored."
Mr Carter died peacefully at Charing Cross Hospital in London on Wednesday night.