Villiame Veikoso will make his first start for the Knights as they look to close out the British and Irish Cup group stage with a 100 per cent record against Cross Keys at Castle Park.
Fijian forward Veikoso will replace Ben Hunter who suffered a blow to the head in the win over Cornish Pirates last weekend.
Boss Clive Griffiths will bring back three players into his squad from the treatment room.
Andy Bulumakau is back after a near two month absence while Ross Davies and Brad Field have also been passed fit.
Bevon Armitage and Tyson Lewis will both start.
WillGriff John is set to make his second start for the club at tight head with Richard List completing the front row with Veikoso.
Matt Challinor returns to the starting XV having scoring a last-gasp try off the bench against the Pirates while Latu Makaafi and Michael Hills are recalled into the pack.
The Knights need just a single point to guarantee a home tie in the quarter final but a victory will make it a perfect six wins from six B&I Cup games during this campaign.
Knights to face Cross Keys: Jarvis, Flockhart, Bulumakau, Armitage, Lewis, Francis, Palu, List, Veikoso, John, Challinor, Phelan, Makaafi, Hills, Shaw.
Replacements: Brugnara, Bergmanas, Davies, Hotson, Eggleshaw, Roberts, Field.