Vehicles have been halted on the northbound carriageway between Barnsdale Bar and Wentbridge and Darrington.
Highways England said that police, ambulance and fire crews were all at the scene.
A spokesman tweeted: “There are 30 minute delays on the approach above usual journey times, spanning three miles. Average speeds on approach are less than 10mph.”
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The road has been closed at the junction with the B6474.