The charity needs volunteers to encourage people in the town to give a donation and wear a daffodil pin.
Money raised will help Marie Curie nurses provide care and support to people living with a terminal illness.
The appeal is now in its 30th year and has raised more than £73 million since 1986.
Katie Grinter, community fundraiser for Marie Curie in Doncaster, said: “The Great Daffodil Appeal is our biggest annual fundraising campaign, making it possible for Marie Curie nurses to give care and support when people need it most.
“Every year millions of people across the UK show their support for our work by simply giving a donation to wear a daffodil pin. This year we are hoping to raise £8.5.”
Call 01274 386190.