The Doncaster branch of Mothercare is to close by next summer.
The struggling mother and baby retailer has announced it is closing 60 stores across the country - with the town's branch at Danum Retail Park off York Road one of those earmarked for closure.
The firm has said its Childrens World division was being placed into administration and 900 jobs nationwide are at risk. The firm has said the stores will close by June 2019.
Branches in Rotherham and Crystal Peaks in Sheffield will also shut.
Other stores will try to agree rent reductions including the branch at Meadowhall.
For many years, the firm's branch was based on the High Street opposite the Danum Hotel.