Doncaster Knights will break new ground when entertaining Ealing Trailfinders in Saturday's Championship clash.
It will be the first-ever meeting of the two clubs, who exchanged positions in 2013-14 following Knights' relegation to National One and Ealing's promotion to the Championship for the first time.
The game is likely to see a return to Castle Park for former fly-half Tristan Roberts, who joined the London side in the summer after playing 19 games for London Welsh in their ill-fated Premiership campaign.
But Roberts will not be playing against either of the two fly-halves brought in by director of rugby Clive Griffiths during the summer with Declan Cusack joining Simon Humberstone, injured in pre-season, on the sidelines after suffering a fractured eye socket in the second game of the season at Nottingham.
“It's frustrating but unfortunately injuries are part and parcel of the game,” said the former Plymouth Albion half-back, who wasted no time in impressing against Welsh in a game he felt they should have won.
With Humberstone also showing up well in pre-season games, competition for the No 10 shirt looks set to be intense when both men are fit - a point not lost on Cusack.
“With Simon being ruled out following a shoulder operation I got first chance to stake a claim for the No 10 shirt and I was looking to kick on after the Welsh game,” he said.
“That hasn't happened but I'm sure I'll get another chance when I'm fit again.
“I've not been given a time-line but I'm hoping to be back playing by the end of the month and in the meantime I'm doing as much work as I can on the weaker areas off my game.”
Rather than bring in someone on loan, Griffiths has opted to switch scrum-half Michael Healey to fly-half - a move supported by Cusack.
“It's a difficult thing to do but Michael has shown that he's got both the skills and the temperament to play there; he's a class operator,” he said.